Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Six2  sine oculis-related homeobox 2
Results	Reference
1	J:117734 James RG, Kamei CN, Wang Q, Jiang R, Schultheiss TM, Odd-skipped related 1 is required for development of the metanephric kidney and regulates formation and differentiation of kidney precursor cells. Development. 2006 Aug;133(15):2995-3004
1	J:86619 Li X, Oghi KA, Zhang J, Krones A, Bush KT, Glass CK, Nigam SK, Aggarwal AK, Maas R, Rose DW, Rosenfeld MG, Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. Nature. 2003 Nov 20;426(6964):247-54
1	J:159508 Nonomura K, Takahashi M, Wakamatsu Y, Takano-Yamamoto T, Osumi N, Dynamic expression of Six family genes in the dental mesenchyme and the epithelial ameloblast stem/progenitor cells during murine tooth development. J Anat. 2010 Jan;216(1):80-91
1*	J:23775 Oliver G, Wehr R, Jenkins NA, Copeland NG, Cheyette BN, Hartenstein V, Zipursky SL, Gruss P, Homeobox genes and connective tissue patterning. Development. 1995 Mar;121(3):693-705
1	J:107078 Poladia DP, Kish K, Kutay B, Hains D, Kegg H, Zhao H, Bates CM, Role of fibroblast growth factor receptors 1 and 2 in the metanephric mesenchyme. Dev Biol. 2006 Mar 15;291(2):325-39
1	J:115344 Self M, Lagutin OV, Bowling B, Hendrix J, Cai Y, Dressler GR, Oliver G, Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney. EMBO J. 2006 Nov 1;25(21):5214-28
1*	J:167305 Sims-Lucas S, Cusack B, Baust J, Eswarakumar VP, Masatoshi H, Takeuchi A, Bates CM, Fgfr1 and the IIIc isoform of Fgfr2 play critical roles in the metanephric mesenchyme mediating early inductive events in kidney development. Dev Dyn. 2011 Jan;240(1):240-9
1*	J:272082 Wang H, Zhang C, Wang X, Lian Y, Guo B, Han M, Zhang X, Zhu X, Xu S, Guo Z, Bi Y, Shen Q, Wang X, Liu J, Zhuang Y, Ni T, Xu H, Wu X, Disruption of Gen1 Causes Congenital Anomalies of the Kidney and Urinary Tract in Mice. Int J Biol Sci. 2018;14(1):10-20
1*	J:88686 Wellik DM, Hawkes PJ, Capecchi MR, Hox11 paralogous genes are essential for metanephric kidney induction. Genes Dev. 2002 Jun 1;16(11):1423-32
1*	J:57313 Xu PX, Adams J, Peters H, Brown MC, Heaney S, Maas R, Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia. Nat Genet. 1999 Sep;23(1):113-7
1*	J:83432 Xu PX, Zheng W, Huang L, Maire P, Laclef C, Silvius D, Six1 is required for the early organogenesis of mammalian kidney. Development. 2003 Jul;130(14):3085-94